PŘF - Postdoctoral Researcher in Bioorganic Chemistry (Modulators of Mitochondrial Enzymes in Neurodegeneration)

University of Hradec Králové, Faculty of Science, Department of Chemistry

Location: Hradec Králové, Czech Republic

Duration: 3 years

Expected start date: January 2027

Position: Part-time or Full-time, on-site

Gross monthly salary: 46 000 CZK plus bonuses

Application deadline: October 2, 2026

About the position:

The Department of Chemistry at the Faculty of Science, University of Hradec Králové, is seeking a motivated and independent Postdoctoral Researcher in Bioorganic or Medicinal Chemistry with a focus on modulators of mitochondrial enzymes in neurodegeneration.

The successful candidate will participate in research combining molecular design, organic synthesis, compound characterization and in vitro evaluation.

Research focus:

The research will focus on the design, preparation, characterization and experimental evaluation of compounds targeting mitochondrial enzymes relevant to neurodegeneration.

The successful candidate will be involved particularly in:

• molecular design;
• organic synthesis;
• characterization of prepared compounds;
• biochemical and other in vitro assays;
• development of synthetic, characterization and evaluation techniques.
• The position also provides an opportunity to develop an independent research programme within the broader scientific scope of the group.

Responsibilities:

The successful candidate will be expected to:

• actively participate in experiments involving molecular design, organic synthesis and/or biochemical assays;
• contribute to the development and modernization of synthetic, characterization and evaluation tools;
• prepare scientific manuscripts;
• collaborate with internal and external researchers;

Candidate profile:

We are looking for a researcher with a PhD in Bioorganic Chemistry, Medicinal Chemistry or a related field.

Essential qualifications:

The candidate should have:

• a PhD in Bioorganic Chemistry, Medicinal Chemistry or a related discipline;
• publications in impact-factor journals indexed in the Web of Science;
• previous experience from a scientific internship abroad;
• practical experience with molecular design, synthetic chemistry, compound characterization and in vitro evaluation;
• English language proficiency at least at C1 level.

We offer:

• the opportunity to participate in research combining molecular design, synthetic chemistry and biochemical evaluation;
• involvement in the development and modernization of synthetic, characterization and evaluation approaches;
• collaboration with researchers within and outside the university;
• the opportunity to develop an independent research programme;
• access to the research environment and infrastructure of the Faculty of Science, University of Hradec Králové.

Application:

Applicants should submit:

• documents listed in Article VII, paragraph 2, items a) to e) of the Vice-Rector’s Directive No. 13/2026
• documents listed in Article 3, paragraph 6 of the Dean’s Decision No. 09/2026.

Applications should be sent by e-mail to: katerina.rybakova@uhk.cz.

Application deadline: October 2, 2026.

Selected candidates will be invited for an interview.

For informal enquiries about the scientific scope of the position, please contact: kamil.musilek@uhk.cz.