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PharmDr. Rudolf Andrýs, Ph.D.

PharmDr. Rudolf Andrýs, Ph.D.
Pracoviště: PřF - Katedra chemie
odborný asistent
E-mail:
Telefon: 493332794
Budova: S
Místnost: 73330 3. podlaží

Konzultační hodiny

Konzultační hodiny po předchozí mailové domluvě.

Akademické profily

Publikace na UHK

HOFMANOVÁ, Tereza, R. ANDRÝS, M. LÍSA. Derivatization agents for LC-MS analysis of amino acids: effects of core structure and functional groups. ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 2026, 418 (8), 2373-2391. ISSN 1618-2642.

SEDLÁČEK MIŠKEŘÍKOVÁ, Markéta, A. HOUFKOVÁ, M. BENKOVA, R. ANDRÝS, J. JANOUSEK, O. SOUKUP, K. MUSÍLEK, O. BENEK. Development of Novel 17β-HSD10 Inhibitors and Their Evaluation in an In Vitro Model of Alzheimer's Disease. ACS Medicinal Chemistry Letters. 2026, 17 (6), 1347-1354. ISSN 1948-5875.

LI, Qifei, W. VAN EYNDE, T. VAN LOY, S. CLAES, A. SKARKA, R. ANDRÝS, K. MUSÍLEK, E. POLLENUS, SM. SCHLENNER, D. SCHOLS, A. VOET, W. DEHAEN, S. DE JONGHE. Discovery of 1-(3-phenoxybenzyl)-4-(1-phenyl-1H-1,2,3-triazol-4-yl)piperidine analogues as potent and selective agonists of the human CC chemokine receptor 8. European Journal of Medicinal Chemistry. 2026, 316 (October), "Article Number: 119064". ISSN 0223-5234.

KNEZ, Damijan, D. MALIŇÁK, A. MEDEN, SF. BENETIK, A. PISLAR, Z. KOHOUTOVÁ, I. VONDRÁČKOVÁ, M. PSOTKA, A. LYČKA, L. PULKRABKOVA, O. SOUKUP, A. SKARKA, R. ANDRÝS, X. BRAZZOLOTTO, A. IGERT, J. DIAS, F. NACHON, J. DETKA, F. TARGOSINSKI, D. HLIABOVICH, JS. BRUNZELLE, L. SHUVALOVA, K. SALAT, SM. ROY, DM. WATTERSON, K. MUSÍLEK, S. GOBEC. Dual Inhibitorsof p38α Mitogen-Activated ProteinKinase and Butyrylcholinesterase for the Modulation of Neuroinflammationand Cognitive Dysfunction. Journal of medicinal chemistry. 2026, 69 (16), 19891−19917. ISSN 0022-2623.

RYSANEK, David, Ž. CHRIENOVÁ, D. STARY, M. BAJDA, J. NOVAK, P. VASICOVA, J. KROUPOVA, R. ANDRÝS, A. SKARKA, E. ROUSAROVA, J. CAPEK, T. ROUSAR, Z. MILOVANOVIC, J. GRUJIC-MILANOVIC, VM. JACEVIC, JN. KOLLA, M. POPR, D. MAURENCOVA, P. OLEKŠÁK, L. FRESSER, K. KUČA, Z. HODNY, E. NEPOVIMOVÁ. In silico screening, synthesis, and biological evaluation of pyrazolopyrimidine-derived mTOR inhibitors for anticancer and senomorphic effects. Cancer Cell International. 2026, 26 (1), "Article number: 247". ISSN 1475-2867.

OLEKŠÁK, Patrik, D. RYSANEK, M. VANCUROVA, J. NOVAK, D. MAURENCOVA, E. ROUSAROVA, J. CAPEK, T. ROUSAR, K. VALES, V. ŠKOPEK, MJ. MASLOWSKA, K. GUMAUSKAITE, G. STANKUS, K. KUČA, R. ANDRÝS, A. SKARKA, M. LÍSA, L. FRESSER, S. SUROVCOVÁ, Ž. CHRIENOVÁ, M. POPR, E. NEPOVIMOVÁ, Z. HODNY. The structure-activity relationship study of torkinib derivatives as mTOR inhibitors with senolytic and STAT3 inhibitory activities. Bioorganic Chemistry. 2026, 176 (July), "Article number: 109868". ISSN 0045-2068.

LOSKOT, Jan, K. KATONOVÁ, D. JEZBERA, R. ANDRÝS, R. SVOBODA, A. TANAKA, A. MYSLIVCOVÁ FUČÍKOVÁ. Degradation behavior and environmental impacts of a hemp-containing "eco-friendly" compostable plastic in natural environments. WASTE MANAGEMENT. 2025, 206 (September), "Article Number: 115045". ISSN 0956-053X.

VERIS, Andrea, J. LOSKOT, R. ANDRÝS, K. KONECNA, O. JANDOUREK, E. SNEJDROVA. Chitosan-based film-forming systems with cannabidiol: a novel topical strategy for antimicrobial therapy. International Journal of Pharmaceutics. 2025, 682 (September), "Article Number: 125940". ISSN 0378-5173.

MONNIER, Charline, R. ANDRÝS, I. CASTELLINO, V. MIČKOVÁ, A. HALEČKOVÁ, J. LOSKOT, O. BENEK, L. ZEMANOVÁ. Immobilized animal liver microsomes: A versatile tool for efficient ester hydrolysis in chemo-enzymatic synthesis☆. METHODS. 2025, 240 (August), 35-46. ISSN 1046-2023.

HALEČKOVÁ, Annamária, K. JURKOVÁ, J. HURDÁLEK, K. CHALUPOVÁ, V. SYROVÁ, D. KOZLOV, J. SVOBODOVÁ, R. ANDRÝS, O. KOZLOV, CH. MONNIER, R. ENDLICHER, A. SKARKA, K. MUSÍLEK, L. ZEMANOVÁ, O. BENEK. N-4-aminobenzyl-N'-(2-(2-phenylpyrrolidin)-2-oxoethyl)urea-based inhibitors of cyclophilin D-Preparation of distinct stereoisomers and comparative analysis of their in vitro bioactivity. Bioorganic Chemistry. 2025, 163 (August), "Article Number: 108743". ISSN 0045-2068.

HOUFKOVÁ, Aneta, M. SCHMIDT, O. BENEK, I. FABRIK, R. ANDRÝS, L. ZEMANOVÁ, O. SOUKUP, K. MUSÍLEK. New insights into the 17β-hydroxysteroid dehydrogenase type 10 and amyloid-β 42 derived cytotoxicity relevant to Alzheimer's disease. Alzheimers Research and Therapy. 2025, 17 (1), "Article Number: 170". ISSN 1758-9193.

BENETIK, Svit Ferjancic, M. PROJ, D. KNEZ, U. KOSAK, A. MEDEN, K. KRAJSEK, A. PISLAR, S. HORVAT, U. SVAJGER, N. TESIC, L. PULKRABKOVA, O. SOUKUP, A. SKARKA, R. ANDRÝS, X. BRAZZOLOTTO, A. IGERT, F. NACHON, J. DIAS, J. DETKA, J. GDULA-ARGASINSKA, E. WYSKA, M. SZAFARZ, A. MANIK, N. PLACHTIJ, K. MUSÍLEK, K. SALAT, A. OBREZA, S. GOBEC. Targeting Neuroinflammation and Cognitive Decline: First-in-Class Dual Butyrylcholinesterase and p38α Mitogen-Activated Protein Kinase Inhibitors. Journal of medicinal chemistry. 2025, 68 (16), 17378-17411. ISSN 0022-2623.

BENETIK, Svit Ferjancic, A. MEDEN, D. KNEZ, P. MASTNAK-SOKOLOV, U. KOSAK, S. HORVAT, A. PISLAR, R. ANDRÝS, K. MUSÍLEK, J. DETKA, K. SALAT, A. OBREZA, S. GOBEC. Transforming ureas into carbamates: From allosteric p38α MAPK ligands to dual BChE/p38α MAPK inhibitors. Bioorganic Chemistry. 2025, 165 (October), "Article Number: 108998". ISSN 0045-2068.

PRCHALOVÁ, Eliška, R. ANDRÝS, J. PEJCHAL, Z. KOHOUTOVÁ, K. KNITTELOVÁ, T. HOFMANOVÁ, A. SKARKA, A. DLABKOVA, M. PSOTKA, L. PRCHAL, K. MUSÍLEK, J. ZDAROVA KARASOVA, D. MALIŇÁK. Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents. Archives of toxicology. 2024, 98 (9), 2937-2952. ISSN 0340-5761.

OLEKŠÁK, Patrik, D. RYSANEK, M. VANCUROVA, P. VASICOVA, A. URBANCOKOVA, J. NOVAK, D. MAURENCOVA, P. KASHMEL, J. HOUSEROVA, R. MIKYSKOVA, O. NOVOTNY, M. REINIS, P. JUDA, M. HONS, J. KROUPOVA, D. SEDLAK, T. SULIMENKO, P. DRABER, M. CHLUBNOVÁ, E. NEPOVIMOVÁ, K. KUČA, M. LÍSA, R. ANDRÝS, T. KOBRLOVA, O. SOUKUP, J. JANOUSEK, L. PRCHAL, J. BARTEK, K. MUSÍLEK, Z. HODNY. Discovery of a 6-Aminobenzo[b]thiophene 1,1-Dioxide Derivative (K2071) with a Signal Transducer and Activator of Transcription 3 Inhibitory, Antimitotic, and Senotherapeutic Activities. ACS pharmacology and translational science. 2024, 7 (9), 2755-2783. ISSN 2575-9108.

SNEJDROVA, Eva, J. LOSKOT, A. VERIS, P. KASTNER, R. ANDRÝS. Formulation study of PLGA in situ films for topical delivery of salicylates. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 2024, 199 (June), "Article Number: 114282". ISSN 0939-6411.

KOHOUTOVÁ, Zuzana, E. PRCHALOVÁ, R. ANDRÝS, K. KNITTELOVÁ, M. FORMANOVÁ, T. HOFMANOVÁ, M. PSOTKA, K. MUSÍLEK, E. DERAT, D. MALIŇÁK. Halogenated monopyridinium oximes are less effective in reactivation of phosphylated cholinesterases than bisquaternary oximes. Bioorganic Chemistry. 2024, 153 (December), "Article Number: 107904". ISSN 0045-2068.

KNITTELOVÁ, Karolína, E. PRCHALOVÁ, A. FUCHSOVÁ, R. ANDRÝS, Z. KOHOUTOVÁ, S. RADEMACHEROVÁ, L. PRCHAL, K. MUSÍLEK, D. MALIŇÁK. Synthesis and Evaluation of Halogenated Pralidoximes in Reactivation of Organophosphate-Inhibited Cholinesterases. ACS Medicinal Chemistry Letters. 2024, 15 (12), 2181-2189. ISSN 1948-5875.

ANDRÝS, Rudolf, CH. MONNIER, E. ANTONIJEVIĆ MILJAKOVIĆ, V. MIČKOVÁ, K. MUSÍLEK, L. ZEMANOVÁ. Towards cost-effective drug discovery: Reusable immobilized enzymes for neurological disease research. Talanta. 2024, 276 (August), "Article Number: 126263". ISSN 0039-9140.

PRCHALOVÁ, Eliška, M. SUKUPOVA, D. MALIŇÁK, R. ANDRÝS, L. SIVAK, V. PEKARIK, A. SKARKA, J. SVOBODOVÁ, L. PRCHAL, L. FRESSER, Z. HEGER, K. MUSÍLEK. BODIPY-labelled acetylcholinesterase reactivators can be encapsulated into ferritin nanovehicles for enhanced bioavailability in the CNS. Biomedicine and Pharmacotherapy. 2023, 167 (November), "Article Number:115490". ISSN 0753-3322.

Životopis

Pozice a funkce na pracovišti

od 2016: Odborný asistent

Vzdělání, kvalifikace

2011 - 2016: Doktorské studium (Ph.D.) Biochemie, Univerzita Karlova

2006 - 2011: Magisterské studium Farmacie, Univerzita Karlova

Zahraniční stáže

2014: šestiměsíční odborná stáž, Univerzita Stockholm, Katedra analytické chemie