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PharmDr. Rudolf Andrýs, Ph.D.
- Workplace: PřF - Department of Chemistry
- assistant professor
- E-mail: rudolf.andrys@uhk.cz
- Phone: 493332794
- Building: S
- Room: 73330 3. floor
Consular Hours
Consultation hours after previous mail arrangement.
Academic profiles
UHK Publications
HOFMANOVÁ, Tereza, R. ANDRÝS, M. LÍSA. Derivatization agents for LC-MS analysis of amino acids: effects of core structure and functional groups. ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 2026, 418 (8), 2373-2391. ISSN 1618-2642.
OLEKŠÁK, Patrik, D. RYSANEK, M. VANCUROVA, J. NOVAK, D. MAURENCOVA, E. ROUSAROVA, J. CAPEK, T. ROUSAR, K. VALES, V. ŠKOPEK, MJ. MASLOWSKA, K. GUMAUSKAITE, G. STANKUS, K. KUČA, R. ANDRÝS, A. SKARKA, M. LÍSA, L. FRESSER, S. SUROVCOVÁ, Ž. CHRIENOVÁ, M. POPR, E. NEPOVIMOVÁ, Z. HODNY. The structure-activity relationship study of torkinib derivatives as mTOR inhibitors with senolytic and STAT3 inhibitory activities. Bioorganic Chemistry. 2026, 176 (July), "Article number: 109868". ISSN 0045-2068.
LOSKOT, Jan, K. KATONOVÁ, D. JEZBERA, R. ANDRÝS, R. SVOBODA, A. TANAKA, A. MYSLIVCOVÁ FUČÍKOVÁ. Degradation behavior and environmental impacts of a hemp-containing "eco-friendly" compostable plastic in natural environments. WASTE MANAGEMENT. 2025, 206 (September), "Article Number: 115045". ISSN 0956-053X.
VERIS, Andrea, J. LOSKOT, R. ANDRÝS, K. KONECNA, O. JANDOUREK, E. SNEJDROVA. Chitosan-based film-forming systems with cannabidiol: a novel topical strategy for antimicrobial therapy. International Journal of Pharmaceutics. 2025, 682 (September), "Article Number: 125940". ISSN 0378-5173.
MONNIER, Charline, R. ANDRÝS, I. CASTELLINO, V. MIČKOVÁ, A. HALEČKOVÁ, J. LOSKOT, O. BENEK, L. ZEMANOVÁ. Immobilized animal liver microsomes: A versatile tool for efficient ester hydrolysis in chemo-enzymatic synthesis☆. METHODS. 2025, 240 (August), 35-46. ISSN 1046-2023.
HALEČKOVÁ, Annamária, K. JURKOVÁ, J. HURDÁLEK, K. CHALUPOVÁ, V. SYROVÁ, D. KOZLOV, J. SVOBODOVÁ, R. ANDRÝS, O. KOZLOV, CH. MONNIER, R. ENDLICHER, A. SKARKA, K. MUSÍLEK, L. ZEMANOVÁ, O. BENEK. N-4-aminobenzyl-N'-(2-(2-phenylpyrrolidin)-2-oxoethyl)urea-based inhibitors of cyclophilin D-Preparation of distinct stereoisomers and comparative analysis of their in vitro bioactivity. Bioorganic Chemistry. 2025, 163 (August), "Article Number: 108743". ISSN 0045-2068.
HOUFKOVÁ, Aneta, M. SCHMIDT, O. BENEK, I. FABRIK, R. ANDRÝS, L. ZEMANOVÁ, O. SOUKUP, K. MUSÍLEK. New insights into the 17β-hydroxysteroid dehydrogenase type 10 and amyloid-β 42 derived cytotoxicity relevant to Alzheimer's disease. Alzheimers Research and Therapy. 2025, 17 (1), "Article Number: 170". ISSN 1758-9193.
BENETIK, Svit Ferjancic, M. PROJ, D. KNEZ, U. KOSAK, A. MEDEN, K. KRAJSEK, A. PISLAR, S. HORVAT, U. SVAJGER, N. TESIC, L. PULKRABKOVA, O. SOUKUP, A. SKARKA, R. ANDRÝS, X. BRAZZOLOTTO, A. IGERT, F. NACHON, J. DIAS, J. DETKA, J. GDULA-ARGASINSKA, E. WYSKA, M. SZAFARZ, A. MANIK, N. PLACHTIJ, K. MUSÍLEK, K. SALAT, A. OBREZA, S. GOBEC. Targeting Neuroinflammation and Cognitive Decline: First-in-Class Dual Butyrylcholinesterase and p38α Mitogen-Activated Protein Kinase Inhibitors. Journal of medicinal chemistry. 2025, 68 (16), 17378-17411. ISSN 0022-2623.
BENETIK, Svit Ferjancic, A. MEDEN, D. KNEZ, P. MASTNAK-SOKOLOV, U. KOSAK, S. HORVAT, A. PISLAR, R. ANDRÝS, K. MUSÍLEK, J. DETKA, K. SALAT, A. OBREZA, S. GOBEC. Transforming ureas into carbamates: From allosteric p38α MAPK ligands to dual BChE/p38α MAPK inhibitors. Bioorganic Chemistry. 2025, 165 (October), "Article Number: 108998". ISSN 0045-2068.
PRCHALOVÁ, Eliška, R. ANDRÝS, J. PEJCHAL, Z. KOHOUTOVÁ, K. KNITTELOVÁ, T. HOFMANOVÁ, A. SKARKA, A. DLABKOVA, M. PSOTKA, L. PRCHAL, K. MUSÍLEK, J. ZDAROVA KARASOVA, D. MALIŇÁK. Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents. Archives of toxicology. 2024, 98 (9), 2937-2952. ISSN 0340-5761.
OLEKŠÁK, Patrik, D. RYSANEK, M. VANCUROVA, P. VASICOVA, A. URBANCOKOVA, J. NOVAK, D. MAURENCOVA, P. KASHMEL, J. HOUSEROVA, R. MIKYSKOVA, O. NOVOTNY, M. REINIS, P. JUDA, M. HONS, J. KROUPOVA, D. SEDLAK, T. SULIMENKO, P. DRABER, M. CHLUBNOVÁ, E. NEPOVIMOVÁ, K. KUČA, M. LÍSA, R. ANDRÝS, T. KOBRLOVA, O. SOUKUP, J. JANOUSEK, L. PRCHAL, J. BARTEK, K. MUSÍLEK, Z. HODNY. Discovery of a 6-Aminobenzo[b]thiophene 1,1-Dioxide Derivative (K2071) with a Signal Transducer and Activator of Transcription 3 Inhibitory, Antimitotic, and Senotherapeutic Activities. ACS pharmacology and translational science. 2024, 7 (9), 2755-2783. ISSN 2575-9108.
SNEJDROVA, Eva, J. LOSKOT, A. VERIS, P. KASTNER, R. ANDRÝS. Formulation study of PLGA in situ films for topical delivery of salicylates. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 2024, 199 (June), "Article Number: 114282". ISSN 0939-6411.
KOHOUTOVÁ, Zuzana, E. PRCHALOVÁ, R. ANDRÝS, K. KNITTELOVÁ, M. FORMANOVÁ, T. HOFMANOVÁ, M. PSOTKA, K. MUSÍLEK, E. DERAT, D. MALIŇÁK. Halogenated monopyridinium oximes are less effective in reactivation of phosphylated cholinesterases than bisquaternary oximes. Bioorganic Chemistry. 2024, 153 (December), "Article Number: 107904". ISSN 0045-2068.
KNITTELOVÁ, Karolína, E. PRCHALOVÁ, A. FUCHSOVÁ, R. ANDRÝS, Z. KOHOUTOVÁ, S. RADEMACHEROVÁ, L. PRCHAL, K. MUSÍLEK, D. MALIŇÁK. Synthesis and Evaluation of Halogenated Pralidoximes in Reactivation of Organophosphate-Inhibited Cholinesterases. ACS Medicinal Chemistry Letters. 2024, 15 (12), 2181-2189. ISSN 1948-5875.
ANDRÝS, Rudolf, CH. MONNIER, E. ANTONIJEVIĆ MILJAKOVIĆ, V. MIČKOVÁ, K. MUSÍLEK, L. ZEMANOVÁ. Towards cost-effective drug discovery: Reusable immobilized enzymes for neurological disease research. Talanta. 2024, 276 (August), "Article Number: 126263". ISSN 0039-9140.
PRCHALOVÁ, Eliška, M. SUKUPOVA, D. MALIŇÁK, R. ANDRÝS, L. SIVAK, V. PEKARIK, A. SKARKA, J. SVOBODOVÁ, L. PRCHAL, L. FRESSER, Z. HEGER, K. MUSÍLEK. BODIPY-labelled acetylcholinesterase reactivators can be encapsulated into ferritin nanovehicles for enhanced bioavailability in the CNS. Biomedicine and Pharmacotherapy. 2023, 167 (November), "Article Number:115490". ISSN 0753-3322.
BENEK, Ondřej, M. VAŠKOVÁ, M. SEDLÁČEK MIŠKEŘÍKOVÁ, M. SCHMIDT, R. ANDRÝS, A. ROTTEROVÁ, A. SKARKA, J. HATLAPATKOVA, JZ. KARASOVA, M. MEDVECKÝ, L. HROCH, L. VINKLÁŘOVÁ, Z. FISAR, J. HROUDOVA, J. HANDL, J. CAPEK, T. ROUSAR, T. KOBRLOVA, R. DOLEZAL, O. SOUKUP, L. AITKEN, F. GUNN-MOORE, K. MUSÍLEK. Development of submicromolar 17 beta-HSD10 inhibitors and their in vitro and in vivo evaluation. European Journal of Medicinal Chemistry. 2023, 258 (říjen), "Article Number: 115593". ISSN 0223-5234.
KOZLOV, Oleksandr, E. HORÁKOVÁ, S. RADEMACHEROVÁ, D. MALIŇÁK, R. ANDRÝS, E. PRCHALOVÁ, M. LÍSA. Direct Chiral Supercritical Fluid Chromatography-Mass Spectrometry Analysis of Monoacylglycerol and Diacylglycerol Isomers for the Study of Lipase-Catalyzed Hydrolysis of Triacylglycerols. Analytical chemistry. 2023, 95 (11), 5109-5116. ISSN 0003-2700.
CHRIENOVÁ, Žofia, D. RYSANEK, J. NOVAK, P. VASICOVA, P. OLEKŠÁK, R. ANDRÝS, A. SKARKA, J. DUMANOVIC, Z. MILOVANOVIC, V. JACEVIC, M. CHVOJKOVA, K. HOLUBOVA, K. VALEŠ, V. SKOUPILOVÁ, M. VALKO, K. JOMOVA, S. ALOMAR, F. BOTELHO, TC. COSTA FRANCA, K. KUČA, Z. HODNY, E. NEPOVIMOVÁ. Frentizole derivatives with mTOR inhibiting and senomorphic properties. Biomedicine and Pharmacotherapy. 2023, 167 (November), "Article number: 115600". ISSN 0753-3322.
HANZLOVÁ, Michaela, M. SEDLÁČEK MIŠKEŘÍKOVÁ, A. ROTTEROVÁ, K. CHALUPOVÁ, K. JURKOVÁ, M. HAMŠÍKOVÁ, R. ANDRÝS, A. HALEČKOVÁ, J. SVOBODOVÁ, M. SCHMIDT, O. BENEK, K. MUSÍLEK. Nanomolar Benzothiazole-Based Inhibitors of 17β-HSD10 with Cellular Bioactivity. ACS Medicinal Chemistry Letters. 2023, 14 (12), 1724-1732. ISSN 1948-5875.
Resume
Position
from 2016: Assistant professor
Education and Qualifications
2011 - 2016: Philosphiae doctor (Ph.D.) in Biochemistry, Charles University
2006 - 2011: Master degree in Pharmacy, Charles University
Academic Stays Abroad
2014: six month scientific stay, Stockholm University, Deparment of Analytical chemistry
