Back
PharmDr. Rudolf Andrýs, Ph.D.
- Workplace: PřF - Department of Chemistry
- assistant professor
- E-mail: rudolf.andrys@uhk.cz
- Phone: 493332794
- Building: S
- Room: 73330 3. floor
Consular Hours
Consultation hours after previous mail arrangement.
Academic profiles
UHK Publications
PRCHALOVÁ, Eliška, M. SUKUPOVA, D. MALIŇÁK, R. ANDRÝS, L. SIVAK, V. PEKARIK, A. SKARKA, J. SVOBODOVÁ, L. PRCHAL, L. FRESSER, Z. HEGER, K. MUSÍLEK. BODIPY-labelled acetylcholinesterase reactivators can be encapsulated into ferritin nanovehicles for enhanced bioavailability in the CNS. Biomedicine and Pharmacotherapy. 2023, 167 (November), "Article Number:115490". ISSN 0753-3322.
BENEK, Ondřej, M. VAŠKOVÁ, M. SEDLÁČEK MIŠKEŘÍKOVÁ, M. SCHMIDT, R. ANDRÝS, A. ROTTEROVÁ, A. SKARKA, J. HATLAPATKOVA, JZ. KARASOVA, M. MEDVECKÝ, L. HROCH, L. VINKLÁŘOVÁ, Z. FISAR, J. HROUDOVA, J. HANDL, J. CAPEK, T. ROUSAR, T. KOBRLOVA, R. DOLEZAL, O. SOUKUP, L. AITKEN, F. GUNN-MOORE, K. MUSÍLEK. Development of submicromolar 17 beta-HSD10 inhibitors and their in vitro and in vivo evaluation. European Journal of Medicinal Chemistry. 2023, 258 (říjen), "Article Number: 115593". ISSN 0223-5234.
KOZLOV, Oleksandr, E. HORÁKOVÁ, S. RADEMACHEROVÁ, D. MALIŇÁK, R. ANDRÝS, E. PRCHALOVÁ, M. LÍSA. Direct Chiral Supercritical Fluid Chromatography-Mass Spectrometry Analysis of Monoacylglycerol and Diacylglycerol Isomers for the Study of Lipase-Catalyzed Hydrolysis of Triacylglycerols. Analytical chemistry. 2023, 95 (11), 5109-5116. ISSN 0003-2700.
CHRIENOVÁ, Žofia, D. RYSANEK, J. NOVAK, P. VASICOVA, P. OLEKŠÁK, R. ANDRÝS, A. SKARKA, J. DUMANOVIC, Z. MILOVANOVIC, V. JACEVIC, M. CHVOJKOVA, K. HOLUBOVA, K. VALEŠ, V. SKOUPILOVÁ, M. VALKO, K. JOMOVA, S. ALOMAR, F. BOTELHO, TC. COSTA FRANCA, K. KUČA, Z. HODNY, E. NEPOVIMOVÁ. Frentizole derivatives with mTOR inhibiting and senomorphic properties. Biomedicine and Pharmacotherapy. 2023, 167 (November), "Article number: 115600". ISSN 0753-3322.
HANZLOVÁ, Michaela, M. SEDLÁČEK MIŠKEŘÍKOVÁ, A. ROTTEROVÁ, K. CHALUPOVÁ, K. JURKOVÁ, M. HAMŠÍKOVÁ, R. ANDRÝS, A. HALEČKOVÁ, J. SVOBODOVÁ, M. SCHMIDT, O. BENEK, K. MUSÍLEK. Nanomolar Benzothiazole-Based Inhibitors of 17β-HSD10 with Cellular Bioactivity. ACS Medicinal Chemistry Letters. 2023, 14 (12), 1724-1732. ISSN 1948-5875.
MIKYSKOVA, Romana, O. SAPEGA, M. PSOTKA, O. NOVOTNY, Z. HODNY, S. BALINTOVA, D. MALIŇÁK, J. SVOBODOVÁ, R. ANDRÝS, D. RYSANEK, K. MUSÍLEK, M. REINIS. STAT3 inhibitor Stattic and its analogues inhibit STAT3 phosphorylation and modulate cytokine secretion in senescent tumour cells. Molecular Medicine Reports. 2023, 27 (4), "Article Number: 81". ISSN 1791-2997.
SVOBODOVA, Barbora, L. PULKRABKOVA, D. PANEK, A. MISIACHNA, M. KOLCHEVA, R. ANDRÝS, J. HANDL, J. CAPEK, P. NYVLTOVA, T. ROUSAR, L. PRCHAL, V. HEPNAROVA, M. HRABINOVA, L. MUCKOVA, D. TOSNEROVA, G. KARABANOVICH, V. FINGER, O. SOUKUP, M. HORAK, J. KORABECNY. Structure-Guided Design of N-Methylpropargylamino- Quinazoline Derivatives as Multipotent Agents for the Treatment of Alzheimer's Disease. International journal of molecular sciences. 2023, 24 (11), "Article Number: 9124". ISSN 1661-6596.
LOSKOT, Jan, D. JEZBERA, ZO. ZMRHALOVA, M. NALEZINKOVÁ, D. ALFERI, K. LELKES, P. VODA, R. ANDRÝS, A. MYSLIVCOVÁ FUČÍKOVÁ, T. HOSSZU, A. BEZROUK. A Complex In Vitro Degradation Study on Polydioxanone Biliary Stents during a Clinically Relevant Period with the Focus on Raman Spectroscopy Validation. POLYMERS. 2022, 14 (5), "Article Number: 938". ISSN 2073-4360.
PEJCHAL, Jaroslav, P. JOŠT, L. MÚČKOVÁ, R. ANDRÝS, M. LÍSA, J. KARASOVÁ ŽĎÁROVÁ. A systematic evaluation of the cucurbit[7]uril pharmacokinetics and toxicity after a single dose and short-term repeated administration in mice. Archives of toxicology. 2022, 96 (5), 1411-1421. ISSN 0340-5761.
PROKES, Libor, E. SNEJDROVA, T. SOUKUP, J. MALAKOVA, V. FROLOV, J. LOSKOT, R. ANDRÝS, T. KUCERA. Allogeneic Bone Impregnated with Biodegradable Depot Delivery Systems for the Local Treatment of Joint Replacement Infections: An In Vitro Study. MOLECULES. 2022, 27 (19), "Article Number: 6487". ISSN 1420-3049.
CHRIENOVÁ, Žofia, D. RYSANEK, P. OLEKŠÁK, D. STARY, M. BAJDA, M. REINIS, R. MIKYSKOVA, O. NOVOTNY, R. ANDRÝS, A. SKARKA, P. VASICOVA, J. NOVAK, M. VALIS, K. KUČA, Z. HODNY, E. NEPOVIMOVÁ. Discovery of small molecule mechanistic target of rapamycin inhibitors as anti-aging and anti-cancer therapeutics. Frontiers in aging neuroscience. 2022, 14 (December), "Article Number: 1048260". ISSN 1663-4365.
ZORBAZ, Tamara, D. MALIŇÁK, T. HOFMANOVÁ, N. MARAKOVIC, S. ZUNEC, NM. HRVAT, R. ANDRÝS, M. PSOTKA, A. ZANDONA, J. SVOBODOVÁ, L. PRCHAL, S. FINGLER, M. KATALINIC, Z. KOVARIK, K. MUSÍLEK. Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents. European Journal of Medicinal Chemistry. 2022, 238 (August), "Article Number: 114377". ISSN 0223-5234.
KOHOUTOVÁ, Zuzana, D. MALIŇÁK, R. ANDRÝS, J. SVOBODOVÁ, M. PSOTKA, M. SCHMIDT, L. PRCHAL, K. MUSÍLEK. Charged pyridinium oximes with thiocarboxamide moiety are equally or less effective reactivators of organophosphate-inhibited cholinesterases compared to analogous carboxamides. Journal of enzyme inhibition and medicinal chemistry. 2022, 37 (1), 760-767. ISSN 1475-6366.
CHRIENOVÁ, Ž.RYŠÁNEK, D.SKOUPILOVÁ, V.OLEKŠÁK, P.ANDRÝS, R.SKARKA, A.BOTELHO, F.COSTA FRANCA, T.C.VANČUROVÁ, M.KUČA, K.HODNÝ, Z.NEPOVIMOVÁ, E.: Mitochondrial modulators with mTOR inhibiting properties in anti-aging therapy. 2022.
VANOVA, Jana, D. MALIŇÁK, R. ANDRÝS, M. KUBAT, T. MIKYSEK, E. ROUSAROVA, K. MUSÍLEK, T. ROUSAR, P. CESLA. Optimization of gradient reversed phase high performance liquid chromatography analysis of acetaminophen oxidation metabolites using linear and non-linear retention model. Journal of Chromatography A. 2022, 1669 (April), "Article Number: 462956". ISSN 0021-9673.
CHRIENOVÁ, Žofia, E. NEPOVIMOVÁ, R. ANDRÝS, R. DOLEZAL, J. JANOCKOVA, L. MUCKOVA, L. FABOVA, O. SOUKUP, P. OLEKŠÁK, M. VALIS, J. KORABECNY, J. MARCO-CONTELLES, K. KUČA. Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities. Journal of enzyme inhibition and medicinal chemistry. 2022, 37 (1), 2605-2620. ISSN 1475-6366.
KARASOVA, Jana Zdarova, J. KASSA, V. HEPNAROVA, J. PEJCHAL, L. JUNOVA, R. ANDRÝS, D. MALIŇÁK, P. BZONEK, Z. KOHOUTOVÁ, K. MUSÍLEK. Toxicity, pharmacokinetics, and effectiveness of the ortho-chlorinated bispyridinium oxime, K870. Food and chemical toxicology. 2022, 167 (September), "Article Number: 113236". ISSN 0278-6915.
ISMAILI, Lhassane, J. MONNIN, A. ETIEVANT, RL. ARRIBAS, L. VIEJO, B. REFOUVELET, O. SOUKUP, J. JANOCKOVA, V. HEPNAROVA, J. KORABECNY, T. KUCERA, D. JUN, R. ANDRÝS, K. MUSÍLEK, A. BAGUET, EM. GARCIA-FRUTOS, A. DE SIMONE, V. ANDRISANO, M. BARTOLINI, C. DE LOS RIOS, J. MARCO-CONTELLES, E. HAFFEN. (+/-)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3 beta Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease. ACS Chemical Neuroscience. 2021, 12 (8), 1328-1342. ISSN 1948-7193.
MEZEIOVA, E., J. JANOCKOVA, R. ANDRÝS, O. SOUKUP, T. KOBRLOVA, L. MUCKOVA, J. PEJCHAL, M. SIMUNKOVA, J. HANDL, P. MICANKOVA, J. CAPEK, T. ROUSAR, M. HRABINOVA, E. NEPOVIMOVÁ, J. MARCO-CONTELLES, M. VALKO, J. KORABECNY. 2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer's disease. European journal of medicinal chemistry. 2021, 211 (February), "Article number 113112". ISSN 0223-5234.
AL MAMUN, Abdullah, F. PIDANY, D. HULCOVA, J. MARIKOVA, T. KUCERA, M. SCHMIDT, MC. CATAPANO, M. HRABINOVA, D. JUN, L. MUCKOVA, J. KUNES, J. JANOUSEK, R. ANDRÝS, L. NOVAKOVA, R. PERINOVA, N. MAAFI, O. SOUKUP, J. KORABECNY, L. CAHLIKOVA. Amaryllidaceae Alkaloids of Norbelladine-Type as Inspiration for Development of Highly Selective Butyrylcholinesterase Inhibitors: Synthesis, Biological Activity Evaluation, and Docking Studies. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021, 22 (15), "Article Number: 8308". ISSN 1422-0067.
Resume
Position
from 2016: Assistant professor
Education and Qualifications
2011 - 2016: Philosphiae doctor (Ph.D.) in Biochemistry, Charles University
2006 - 2011: Master degree in Pharmacy, Charles University
Academic Stays Abroad
2014: six month scientific stay, Stockholm University, Deparment of Analytical chemistry
