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PharmDr. Rudolf Andrýs, Ph.D.

PharmDr. Rudolf Andrýs, Ph.D.
Academic Senate of the University of Hradec Králové
Academic Staff Representative, PřF
Workplace: PřF - Department of Chemistry
assistant professor
Workplace: PřF - Academic Senate of the Faculty of Science
Academic Staff Representative
E-mail:
Phone: 493332794
Building: S
Room: 73330 3. floor

Consular Hours

Consultation hours after previous mail arrangement.

Academic profiles

UHK Publications

LOSKOT, Jan, K. KATONOVÁ, D. JEZBERA, R. ANDRÝS, R. SVOBODA, A. TANAKA, A. MYSLIVCOVÁ FUČÍKOVÁ. Degradation behavior and environmental impacts of a hemp-containing "eco-friendly" compostable plastic in natural environments. WASTE MANAGEMENT. 2025, 206 (September), "Article Number: 115045". ISSN 0956-053X.

VERIS, Andrea, J. LOSKOT, R. ANDRÝS, K. KONECNA, O. JANDOUREK, E. SNEJDROVA. Chitosan-based film-forming systems with cannabidiol: a novel topical strategy for antimicrobial therapy. International Journal of Pharmaceutics. 2025, 682 (September), "Article Number: 125940". ISSN 0378-5173.

MONNIER, Charline, R. ANDRÝS, I. CASTELLINO, V. MIČKOVÁ, A. HALEČKOVÁ, J. LOSKOT, O. BENEK, L. ZEMANOVÁ. Immobilized animal liver microsomes: A versatile tool for efficient ester hydrolysis in chemo-enzymatic synthesis☆. METHODS. 2025, 240 (August), 35-46. ISSN 1046-2023.

HALEČKOVÁ, Annamária, K. JURKOVÁ, J. HURDÁLEK, K. CHALUPOVÁ, V. SYROVÁ, D. KOZLOV, J. SVOBODOVÁ, R. ANDRÝS, O. KOZLOV, CH. MONNIER, R. ENDLICHER, A. SKARKA, K. MUSÍLEK, L. ZEMANOVÁ, O. BENEK. N-4-aminobenzyl-N'-(2-(2-phenylpyrrolidin)-2-oxoethyl)urea-based inhibitors of cyclophilin D-Preparation of distinct stereoisomers and comparative analysis of their in vitro bioactivity. Bioorganic Chemistry. 2025, 163 (August), "Article Number: 108743". ISSN 0045-2068.

HOUFKOVÁ, Aneta, M. SCHMIDT, O. BENEK, I. FABRIK, R. ANDRÝS, L. ZEMANOVÁ, O. SOUKUP, K. MUSÍLEK. New insights into the 17β-hydroxysteroid dehydrogenase type 10 and amyloid-β 42 derived cytotoxicity relevant to Alzheimer's disease. Alzheimers Research and Therapy. 2025, 17 (1), "Article Number: 170". ISSN 1758-9193.

BENETIK, Svit Ferjancic, M. PROJ, D. KNEZ, U. KOSAK, A. MEDEN, K. KRAJSEK, A. PISLAR, S. HORVAT, U. SVAJGER, N. TESIC, L. PULKRABKOVA, O. SOUKUP, A. SKARKA, R. ANDRÝS, X. BRAZZOLOTTO, A. IGERT, F. NACHON, J. DIAS, J. DETKA, J. GDULA-ARGASINSKA, E. WYSKA, M. SZAFARZ, A. MANIK, N. PLACHTIJ, K. MUSÍLEK, K. SALAT, A. OBREZA, S. GOBEC. Targeting Neuroinflammation and Cognitive Decline: First-in-Class Dual Butyrylcholinesterase and p38α Mitogen-Activated Protein Kinase Inhibitors. Journal of medicinal chemistry. 2025, 68 (16), 17378-17411. ISSN 0022-2623.

PRCHALOVÁ, Eliška, R. ANDRÝS, J. PEJCHAL, Z. KOHOUTOVÁ, K. KNITTELOVÁ, T. HOFMANOVÁ, A. SKARKA, A. DLABKOVA, M. PSOTKA, L. PRCHAL, K. MUSÍLEK, J. ZDAROVA KARASOVA, D. MALIŇÁK. Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents. Archives of toxicology. 2024, 98 (9), 2937-2952. ISSN 0340-5761.

OLEKŠÁK, Patrik, D. RYSANEK, M. VANCUROVA, P. VASICOVA, A. URBANCOKOVA, J. NOVAK, D. MAURENCOVA, P. KASHMEL, J. HOUSEROVA, R. MIKYSKOVA, O. NOVOTNY, M. REINIS, P. JUDA, M. HONS, J. KROUPOVA, D. SEDLAK, T. SULIMENKO, P. DRABER, M. CHLUBNOVÁ, E. NEPOVIMOVÁ, K. KUČA, M. LÍSA, R. ANDRÝS, T. KOBRLOVA, O. SOUKUP, J. JANOUSEK, L. PRCHAL, J. BARTEK, K. MUSÍLEK, Z. HODNY. Discovery of a 6-Aminobenzo[b]thiophene 1,1-Dioxide Derivative (K2071) with a Signal Transducer and Activator of Transcription 3 Inhibitory, Antimitotic, and Senotherapeutic Activities. ACS pharmacology and translational science. 2024, 7 (9), 2755-2783. ISSN 2575-9108.

SNEJDROVA, Eva, J. LOSKOT, A. VERIS, P. KASTNER, R. ANDRÝS. Formulation study of PLGA in situ films for topical delivery of salicylates. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 2024, 199 (June), "Article Number: 114282". ISSN 0939-6411.

KOHOUTOVÁ, Zuzana, E. PRCHALOVÁ, R. ANDRÝS, K. KNITTELOVÁ, M. FORMANOVÁ, T. HOFMANOVÁ, M. PSOTKA, K. MUSÍLEK, E. DERAT, D. MALIŇÁK. Halogenated monopyridinium oximes are less effective in reactivation of phosphylated cholinesterases than bisquaternary oximes. Bioorganic Chemistry. 2024, 153 (December), "Article Number: 107904". ISSN 0045-2068.

KNITTELOVÁ, Karolína, E. PRCHALOVÁ, A. FUCHSOVÁ, R. ANDRÝS, Z. KOHOUTOVÁ, S. RADEMACHEROVÁ, L. PRCHAL, K. MUSÍLEK, D. MALIŇÁK. Synthesis and Evaluation of Halogenated Pralidoximes in Reactivation of Organophosphate-Inhibited Cholinesterases. ACS Medicinal Chemistry Letters. 2024, 15 (12), 2181-2189. ISSN 1948-5875.

ANDRÝS, Rudolf, CH. MONNIER, E. ANTONIJEVIĆ MILJAKOVIĆ, V. MIČKOVÁ, K. MUSÍLEK, L. ZEMANOVÁ. Towards cost-effective drug discovery: Reusable immobilized enzymes for neurological disease research. Talanta. 2024, 276 (August), "Article Number: 126263". ISSN 0039-9140.

PRCHALOVÁ, Eliška, M. SUKUPOVA, D. MALIŇÁK, R. ANDRÝS, L. SIVAK, V. PEKARIK, A. SKARKA, J. SVOBODOVÁ, L. PRCHAL, L. FRESSER, Z. HEGER, K. MUSÍLEK. BODIPY-labelled acetylcholinesterase reactivators can be encapsulated into ferritin nanovehicles for enhanced bioavailability in the CNS. Biomedicine and Pharmacotherapy. 2023, 167 (November), "Article Number:115490". ISSN 0753-3322.

BENEK, Ondřej, M. VAŠKOVÁ, M. SEDLÁČEK MIŠKEŘÍKOVÁ, M. SCHMIDT, R. ANDRÝS, A. ROTTEROVÁ, A. SKARKA, J. HATLAPATKOVA, JZ. KARASOVA, M. MEDVECKÝ, L. HROCH, L. VINKLÁŘOVÁ, Z. FISAR, J. HROUDOVA, J. HANDL, J. CAPEK, T. ROUSAR, T. KOBRLOVA, R. DOLEZAL, O. SOUKUP, L. AITKEN, F. GUNN-MOORE, K. MUSÍLEK. Development of submicromolar 17 beta-HSD10 inhibitors and their in vitro and in vivo evaluation. European Journal of Medicinal Chemistry. 2023, 258 (říjen), "Article Number: 115593". ISSN 0223-5234.

KOZLOV, Oleksandr, E. HORÁKOVÁ, S. RADEMACHEROVÁ, D. MALIŇÁK, R. ANDRÝS, E. PRCHALOVÁ, M. LÍSA. Direct Chiral Supercritical Fluid Chromatography-Mass Spectrometry Analysis of Monoacylglycerol and Diacylglycerol Isomers for the Study of Lipase-Catalyzed Hydrolysis of Triacylglycerols. Analytical chemistry. 2023, 95 (11), 5109-5116. ISSN 0003-2700.

CHRIENOVÁ, Žofia, D. RYSANEK, J. NOVAK, P. VASICOVA, P. OLEKŠÁK, R. ANDRÝS, A. SKARKA, J. DUMANOVIC, Z. MILOVANOVIC, V. JACEVIC, M. CHVOJKOVA, K. HOLUBOVA, K. VALEŠ, V. SKOUPILOVÁ, M. VALKO, K. JOMOVA, S. ALOMAR, F. BOTELHO, TC. COSTA FRANCA, K. KUČA, Z. HODNY, E. NEPOVIMOVÁ. Frentizole derivatives with mTOR inhibiting and senomorphic properties. Biomedicine and Pharmacotherapy. 2023, 167 (November), "Article number: 115600". ISSN 0753-3322.

HANZLOVÁ, Michaela, M. SEDLÁČEK MIŠKEŘÍKOVÁ, A. ROTTEROVÁ, K. CHALUPOVÁ, K. JURKOVÁ, M. HAMŠÍKOVÁ, R. ANDRÝS, A. HALEČKOVÁ, J. SVOBODOVÁ, M. SCHMIDT, O. BENEK, K. MUSÍLEK. Nanomolar Benzothiazole-Based Inhibitors of 17β-HSD10 with Cellular Bioactivity. ACS Medicinal Chemistry Letters. 2023, 14 (12), 1724-1732. ISSN 1948-5875.

MIKYSKOVA, Romana, O. SAPEGA, M. PSOTKA, O. NOVOTNY, Z. HODNY, S. BALINTOVA, D. MALIŇÁK, J. SVOBODOVÁ, R. ANDRÝS, D. RYSANEK, K. MUSÍLEK, M. REINIS. STAT3 inhibitor Stattic and its analogues inhibit STAT3 phosphorylation and modulate cytokine secretion in senescent tumour cells. Molecular Medicine Reports. 2023, 27 (4), "Article Number: 81". ISSN 1791-2997.

SVOBODOVA, Barbora, L. PULKRABKOVA, D. PANEK, A. MISIACHNA, M. KOLCHEVA, R. ANDRÝS, J. HANDL, J. CAPEK, P. NYVLTOVA, T. ROUSAR, L. PRCHAL, V. HEPNAROVA, M. HRABINOVA, L. MUCKOVA, D. TOSNEROVA, G. KARABANOVICH, V. FINGER, O. SOUKUP, M. HORAK, J. KORABECNY. Structure-Guided Design of N-Methylpropargylamino- Quinazoline Derivatives as Multipotent Agents for the Treatment of Alzheimer's Disease. International journal of molecular sciences. 2023, 24 (11), "Article Number: 9124". ISSN 1661-6596.

LOSKOT, Jan, D. JEZBERA, ZO. ZMRHALOVA, M. NALEZINKOVÁ, D. ALFERI, K. LELKES, P. VODA, R. ANDRÝS, A. MYSLIVCOVÁ FUČÍKOVÁ, T. HOSSZU, A. BEZROUK. A Complex In Vitro Degradation Study on Polydioxanone Biliary Stents during a Clinically Relevant Period with the Focus on Raman Spectroscopy Validation. POLYMERS. 2022, 14 (5), "Article Number: 938". ISSN 2073-4360.

Resume

Position

from 2016: Assistant professor

Education and Qualifications

2011 - 2016: Philosphiae doctor (Ph.D.) in Biochemistry, Charles University

2006 - 2011: Master degree in Pharmacy, Charles University

Academic Stays Abroad

2014: six month scientific stay, Stockholm University, Deparment of Analytical chemistry