Oxime antidotes for reactivation of cholinesterases inhibited by highly poisonous organophosphates (REACT)

• hlavní řešitel: prof. PharmDr. Kamil Musílek, Ph.D. (katedra chemie PřF UHK)
• hlavní zahraniční spoluřešitel: Goran Šinko (Institute for Medical Research and Occupational Health)
• reg. číslo: 26-20584K
• období řešení: 01/2026-12/2028
• typ projektu: Lead Agency

The highly toxic organophosphorus compounds were used during serious incidents in the last decade. These agents are causing life endangering intoxication that are usually treated by combination of antidotes, where only reactivators (oximes) are able to split organophosphates from cholinesterase active site and restore their physiologic activity. However, the standard oximes were found ineffective antidotes for such highly toxic organophosphorus compounds.
For these reasons, the current research is based on searching for oximes with increased reactivation for the specific organophosphates. Thus, this project is focused on proof of concept of increased organophosphate reactivation and organism protection using double charged pyridinium oximes, which will be designed, prepared and thoroughly evaluated for these purposes.