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prof. PharmDr. Kamil Musílek, Ph.D.
- Workplace: PřF - Department of Chemistry
- professor
- head of the Department of Chemistry
- E-mail: kamil.musilek@uhk.cz
- Phone: 493332780
- Building: S
- Room: 73840 3. floor
Academic profiles
UHK Publications
GRUBEROVA, Eliska, V. PEKARIK, K. MUSÍLEK, Z. HEGER. Biomedical applications of mammalian, bacterial, and archaeal ferritins - Targeted drug delivery and beyond. Nano Today. 2025, 61 (April), "Article Number: 102648". ISSN 1748-0132.
HALEČKOVÁ, Annamária, K. JURKOVÁ, J. HURDÁLEK, K. CHALUPOVÁ, V. SYROVÁ, D. KOZLOV, J. SVOBODOVÁ, R. ANDRÝS, O. KOZLOV, CH. MONNIER, R. ENDLICHER, A. SKARKA, K. MUSÍLEK, L. ZEMANOVÁ, O. BENEK. N-4-aminobenzyl-N'-(2-(2-phenylpyrrolidin)-2-oxoethyl)urea-based inhibitors of cyclophilin D-Preparation of distinct stereoisomers and comparative analysis of their in vitro bioactivity. Bioorganic Chemistry. 2025, 163 (August), "Article Number: 108743". ISSN 0045-2068.
HOUFKOVÁ, Aneta, M. SCHMIDT, O. BENEK, I. FABRIK, R. ANDRÝS, L. ZEMANOVÁ, O. SOUKUP, K. MUSÍLEK. New insights into the 17β-hydroxysteroid dehydrogenase type 10 and amyloid-β 42 derived cytotoxicity relevant to Alzheimer's disease. Alzheimers Research and Therapy. 2025, 17 (1), "Article Number: 170". ISSN 1758-9193.
CHAKRASALI, Prashant, D. HWANG, J. LEE, E. JUNG, HL. LEE, A. RENEESH, A. SKARKA, K. MUSÍLEK, NH. NGUYEN, JS. SHIN, Y. JUNG. 7-Amino-3-phenyl-2-methyl-pyrazolopyrimidine derivatives inhibit human rhinovirus replication. European Journal of Medicinal Chemistry. 2024, 276 (October), "Article Number: 116690". ISSN 0223-5234.
PRCHALOVÁ, Eliška, R. ANDRÝS, J. PEJCHAL, Z. KOHOUTOVÁ, K. KNITTELOVÁ, T. HOFMANOVÁ, A. SKARKA, A. DLABKOVA, M. PSOTKA, L. PRCHAL, K. MUSÍLEK, J. ZDAROVA KARASOVA, D. MALIŇÁK. Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents. Archives of toxicology. 2024, 98 (9), 2937-2952. ISSN 0340-5761.
HANZLOVÁ, Michaela, B. SLAVIKOVÁ, M. MOROZOVOVÁ, K. MUSÍLEK, A. ROTTEROVÁ, L. ZEMANOVÁ, E. KUDOVÁ. C-3 Steroidal Hemiesters as Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 10. ACS Omega. 2024, 9 (10), 12116-12124. ISSN 2470-1343.
UNIVERZITA HRADEC KRÁLOVÉ. Deriváty 2-arylbenzothiazolu, způsob jejich přípravy a jejich použití, Původci: MUSÍLEK, Kamil, O. BENEK, L. ZEMANOVÁ2024. Číslo patentu: 310144.
OLEKŠÁK, Patrik, D. RYSANEK, M. VANCUROVA, P. VASICOVA, A. URBANCOKOVA, J. NOVAK, D. MAURENCOVA, P. KASHMEL, J. HOUSEROVA, R. MIKYSKOVA, O. NOVOTNY, M. REINIS, P. JUDA, M. HONS, J. KROUPOVA, D. SEDLAK, T. SULIMENKO, P. DRABER, M. CHLUBNOVÁ, E. NEPOVIMOVÁ, K. KUČA, M. LÍSA, R. ANDRÝS, T. KOBRLOVA, O. SOUKUP, J. JANOUSEK, L. PRCHAL, J. BARTEK, K. MUSÍLEK, Z. HODNY. Discovery of a 6-Aminobenzo[b]thiophene 1,1-Dioxide Derivative (K2071) with a Signal Transducer and Activator of Transcription 3 Inhibitory, Antimitotic, and Senotherapeutic Activities. ACS pharmacology and translational science. 2024, 7 (9), 2755-2783. ISSN 2575-9108.
KOHOUTOVÁ, Zuzana, E. PRCHALOVÁ, R. ANDRÝS, K. KNITTELOVÁ, M. FORMANOVÁ, T. HOFMANOVÁ, M. PSOTKA, K. MUSÍLEK, E. DERAT, D. MALIŇÁK. Halogenated monopyridinium oximes are less effective in reactivation of phosphylated cholinesterases than bisquaternary oximes. Bioorganic Chemistry. 2024, 153 (December), "Article Number: 107904". ISSN 0045-2068.
UNIVERZITA HRADEC KRÁLOVÉ. Heterocyklická sloučenina pro inhibici růstu maligních tumorů, Původci: MUSÍLEK, Kamil, P. OLEKŠÁK, V. PAVLA, R. MILAN, R. DAVID2024. Číslo patentu: 310092.
HALEČKOVÁ, Annamária, V. SYROVÁ, A. JOKLOVÁ, T. VERNEROVÁ, J. HURDÁLEK, R. ENDLICHER, K. ŠALAMONOVÁ, P. BŮBELOVÁ, HFF. KURNIA, M. SCHMIDT, K. MUSÍLEK, L. ZEMANOVÁ, O. BENEK. Neuroprotective Effect of 2-(Benzyloxy)arylureas Is Not Related to CypD Inhibition nor Suppression of mPTP Opening. ACS Medicinal Chemistry Letters. 2024, 15 (10), 1756-1763. ISSN 1948-5875.
ZARSKA, Monika, O. NOVAK, T. JAKUBCOVA, F. NOVOTNY, A. URBANCOKOVA, F. HAVEL, J. NOVAK, H. RAABOVA, K. MUSÍLEK, V. FILIMONENKO, J. BARTEK, J. PROSKA, Z. HODNY. Photothermal induction of pyroptosis in malignant glioma spheroids using (16-mercaptohexadecyl)trimethylammonium bromide-modified cationic gold nanorods. Colloids and Surfaces B: Biointerfaces. 2024, 243 (November), "Article Number: 114128". ISSN 0927-7765.
KOHOUTOVÁ, Zuzana, E. PRCHALOVÁ, K. KNITTELOVÁ, K. MUSÍLEK, D. MALIŇÁK. Reactivators of butyrylcholinesterase inhibited by organophosphorus compounds. Bioorganic Chemistry. 2024, 150 (September), "Article Number: 107526". ISSN 0045-2068.
KNITTELOVÁ, Karolína, E. PRCHALOVÁ, A. FUCHSOVÁ, R. ANDRÝS, Z. KOHOUTOVÁ, S. RADEMACHEROVÁ, L. PRCHAL, K. MUSÍLEK, D. MALIŇÁK. Synthesis and Evaluation of Halogenated Pralidoximes in Reactivation of Organophosphate-Inhibited Cholinesterases. ACS Medicinal Chemistry Letters. 2024, 15 (12), 2181-2189. ISSN 1948-5875.
ANDRÝS, Rudolf, CH. MONNIER, E. ANTONIJEVIĆ MILJAKOVIĆ, V. MIČKOVÁ, K. MUSÍLEK, L. ZEMANOVÁ. Towards cost-effective drug discovery: Reusable immobilized enzymes for neurological disease research. Talanta. 2024, 276 (August), "Article Number: 126263". ISSN 0039-9140.
PRCHALOVÁ, Eliška, M. SUKUPOVA, D. MALIŇÁK, R. ANDRÝS, L. SIVAK, V. PEKARIK, A. SKARKA, J. SVOBODOVÁ, L. PRCHAL, L. FRESSER, Z. HEGER, K. MUSÍLEK. BODIPY-labelled acetylcholinesterase reactivators can be encapsulated into ferritin nanovehicles for enhanced bioavailability in the CNS. Biomedicine and Pharmacotherapy. 2023, 167 (November), "Article Number:115490". ISSN 0753-3322.
ROUSAR, Tomas, J. HANDL, J. CAPEK, P. NYVLTOVA, E. ROUSAROVA, M. KUBAT, L. SMID, J. VANOVA, D. MALIŇÁK, K. MUSÍLEK, P. CESLA. Cysteine conjugates of acetaminophen and p-aminophenol are potent inducers of cellular impairment in human proximal tubular kidney HK-2 cells. Archives of toxicology. 2023, 97 (11), 2943-2954. ISSN 0340-5761.
BENEK, Ondřej, M. VAŠKOVÁ, M. SEDLÁČEK MIŠKEŘÍKOVÁ, M. SCHMIDT, R. ANDRÝS, A. ROTTEROVÁ, A. SKARKA, J. HATLAPATKOVA, JZ. KARASOVA, M. MEDVECKÝ, L. HROCH, L. VINKLÁŘOVÁ, Z. FISAR, J. HROUDOVA, J. HANDL, J. CAPEK, T. ROUSAR, T. KOBRLOVA, R. DOLEZAL, O. SOUKUP, L. AITKEN, F. GUNN-MOORE, K. MUSÍLEK. Development of submicromolar 17 beta-HSD10 inhibitors and their in vitro and in vivo evaluation. European Journal of Medicinal Chemistry. 2023, 258 (říjen), "Article Number: 115593". ISSN 0223-5234.
HANZLOVÁ, Michaela, M. SEDLÁČEK MIŠKEŘÍKOVÁ, A. ROTTEROVÁ, K. CHALUPOVÁ, K. JURKOVÁ, M. HAMŠÍKOVÁ, R. ANDRÝS, A. HALEČKOVÁ, J. SVOBODOVÁ, M. SCHMIDT, O. BENEK, K. MUSÍLEK. Nanomolar Benzothiazole-Based Inhibitors of 17β-HSD10 with Cellular Bioactivity. ACS Medicinal Chemistry Letters. 2023, 14 (12), 1724-1732. ISSN 1948-5875.
SCHMIDT, Monika, M. VAŠKOVÁ, A. ROTTEROVÁ, P. FIANDOVÁ, M. MIŠKEŘÍKOVÁ, L. ZEMANOVÁ, O. BENEK, K. MUSÍLEK. Physiologically relevant fluorescent assay for identification of 17β-hydroxysteroid dehydrogenase type 10 inhibitors. Journal of Neurochemistry. 2023, 167 (2), 154-167. ISSN 0022-3042.
Resume
Position
2019 - 2022: Vice-dean for International Affairs
2011 - 2022: Head of Department of Chemistry
Education and Qualifications
2019: Full Professor in Pharmaceutical Chemistry
2012: Associate Professor in Pharmaceutical Chemistry
2008: PharmDr. in Pharmaceutical Chemistry
2004 - 2007: Ph.D. in Pharmaceutical Chemistry
1999 - 2004: MSc. in Pharmacy
Work Experience
2011 - 2022: academic position, University of Hradec Kralove, Faculty of Science
2011 - 2022: scientific position, University Hospital Hradec Kralove
2006 - 2018: academic position, University of Defence, Faculty of Military Health Sciences
Teaching Experience
Medicinal Chemistry
Organic and Bioorganic Chemistry
Toxicology
Academic Stays Abroad
2009: Centre Recherche Service Santé Armée, La Tronche/Grenoble, FR
2007: University St Andrews, UK
2003 - 2004: Ruprecht-Karls-Universität Heidelberg, DE
