Zpět
Mgr. Monika Schmidt, Ph.D.
- Pracoviště: PřF - Katedra chemie
- odborný asistent
- E-mail: monika.schmidt@uhk.cz
- Telefon: 493332796
- Budova: S
- Místnost: 74470 4. podlaží
Publikace na UHK
BENEK, Ondřej, M. VAŠKOVÁ, M. SEDLÁČEK MIŠKEŘÍKOVÁ, M. SCHMIDT, R. ANDRÝS, A. ROTTEROVÁ, A. SKARKA, J. HATLAPATKOVA, JZ. KARASOVA, M. MEDVECKÝ, L. HROCH, L. VINKLÁŘOVÁ, Z. FISAR, J. HROUDOVA, J. HANDL, J. CAPEK, T. ROUSAR, T. KOBRLOVA, R. DOLEZAL, O. SOUKUP, L. AITKEN, F. GUNN-MOORE, K. MUSÍLEK. Development of submicromolar 17 beta-HSD10 inhibitors and their in vitro and in vivo evaluation. European Journal of Medicinal Chemistry. 2023, 258 (říjen), "Article Number: 115593". ISSN 0223-5234.
HANZLOVÁ, Michaela, M. SEDLÁČEK MIŠKEŘÍKOVÁ, A. ROTTEROVÁ, K. CHALUPOVÁ, K. JURKOVÁ, M. HAMŠÍKOVÁ, R. ANDRÝS, A. HALEČKOVÁ, J. SVOBODOVÁ, M. SCHMIDT, O. BENEK, K. MUSÍLEK. Nanomolar Benzothiazole-Based Inhibitors of 17β-HSD10 with Cellular Bioactivity. ACS Medicinal Chemistry Letters. 2023, 14 (12), 1724-1732. ISSN 1948-5875.
SCHMIDT, Monika, M. VAŠKOVÁ, A. ROTTEROVÁ, P. FIANDOVÁ, M. MIŠKEŘÍKOVÁ, L. ZEMANOVÁ, O. BENEK, K. MUSÍLEK. Physiologically relevant fluorescent assay for identification of 17β-hydroxysteroid dehydrogenase type 10 inhibitors. Journal of Neurochemistry. 2023, 167 (2), 154-167. ISSN 0022-3042.
UNIVERZITA HRADEC KRÁLOVE. ProxyQB – rehabilitační kostka. Původci: GÁL, Vladimír, J. JANECZKO, L. KOVAŘÍK, O. KUBÍČEK, P. KUČA, T. MARIÁNEK, M. ORSZULÍK, V. PRŮŠA, D. PUKALÍK, M. SEIDLEROVÁ, R. SOBOTÍKOVÁ, L. STUCHLÍK, M. ŠČUPÁK, J. ŠEVČÍK, Z. ŠIMÍKOVÁ, J. VANTUCH, R. VAŠEK, P. COUFAL, A. CHOLEVOVÁ, M. KALOVÁ, K. KUČA, L. KYTNAROVÁ, P. MAREŠOVÁ, P. NILIUS, L. PETER, L. REŽNÝ, M. SCHMIDT, M. SCHMIDT, J. SKALSKÝ, A. SKARKA, P. STRAKA, J. VONDRÁK. 2023. Identifikační číslo: EG21_374/0026873.
KOHOUTOVÁ, Zuzana, D. MALIŇÁK, R. ANDRÝS, J. SVOBODOVÁ, M. PSOTKA, M. SCHMIDT, L. PRCHAL, K. MUSÍLEK. Charged pyridinium oximes with thiocarboxamide moiety are equally or less effective reactivators of organophosphate-inhibited cholinesterases compared to analogous carboxamides. Journal of enzyme inhibition and medicinal chemistry. 2022, 37 (1), 760-767. ISSN 1475-6366.
HEPNAROVA, Vendula, M. HRABINOVA, L. MUCKOVA, T. KUCERA, M. SCHMIDT, R. DOLEŽAL, L. GORECKI, V. HRABCOVA, J. KORABECNY, E. MEZEIOVA, D. JUN, J. PEJCHAL. Non-covalent acetylcholinesterase inhibitors: In vitro screening and molecular modeling for novel selective insecticides. Toxicology in vitro. 2022, 85 (prosinec), "Article Number: 105463". ISSN 0887-2333.
AL SHAMMARI, L., D. HULCOVA, J. MARIKOVA, T. KUCERA, M. SAFRATOVA, L. NOVAKOVA, M. SCHMIDT, L. PULKRABKOVA, J. JANOUSEK, O. SOUKUP, J. KUNES, L. OPLETAL, L. CAHLIKOVA. Amaryllidaceae alkaloids from Hippeastrum X Hybridum CV. Ferrari, and preparation of vittatine derivatives as potential ligands for Alzheimer's disease. South African Journal of Botany. 2021, 136 (JANUARY), 137-146. ISSN 0254-6299.
AL MAMUN, Abdullah, F. PIDANY, D. HULCOVA, J. MARIKOVA, T. KUCERA, M. SCHMIDT, MC. CATAPANO, M. HRABINOVA, D. JUN, L. MUCKOVA, J. KUNES, J. JANOUSEK, R. ANDRÝS, L. NOVAKOVA, R. PERINOVA, N. MAAFI, O. SOUKUP, J. KORABECNY, L. CAHLIKOVA. Amaryllidaceae Alkaloids of Norbelladine-Type as Inspiration for Development of Highly Selective Butyrylcholinesterase Inhibitors: Synthesis, Biological Activity Evaluation, and Docking Studies. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021, 22 (15), "Article Number: 8308". ISSN 1422-0067.
MAAFI, Negar, F. PIDANY, J. MARIKOVA, J. KORABECNY, D. HULCOVA, T. KUCERA, M. SCHMIDT, L. AL SHAMMARI, M. SPULAK, MC. CATAPANO, M. MECAVA, L. PRCHALD, J. KUNES, J. JANOUSEK, E. KOHELOVA, J. JENCO, L. NOVAKOVA, L. CAHLIKOVA. Derivatives of montanine-type alkaloids and their implication for the treatment of Alzheimer's disease: Synthesis, biological activity and in silico study. Bioorganic and medicinal chemistry letters. 2021, 51 (November), "Article Number: 128374". ISSN 0960-894X.
FISAR, Zdenek, K. MUSÍLEK, O. BENEK, L. HROCH, L. VINKLÁŘOVÁ, M. SCHMIDT, J. HROUDOVA, J. RABOCH. Effects of novel 17 beta-hydroxysteroid dehydrogenase type 10 inhibitors on mitochondrial respiration. Toxicology letters. 2021, 339 (15.3.2021), 12-19. ISSN 0378-4274.
HRABINOVA, Martina, J. PEJCHAL, T. KUCERA, D. JUN, M. SCHMIDT, O. SOUKUP. Is It the Twilight of BACEI Inhibitors?. CURRENT NEUROPHARMACOLOGY. 2021, 19 (1), 61-77. ISSN 1570-159X.
LEE, Hyun Myung, R. ANDRÝS, J. JONCZYK, K. KIM, AG. VISHAKANTEGOWDA, D. MALIŇÁK, A. SKARKA, M. SCHMIDT, M. VAŠKOVÁ, K. LATKA, M. BAJDA, Y. JUNG, B. MALAWSKA, K. MUSÍLEK. Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve agent surrogates. Journal of enzyme inhibition and medicinal chemistry. 2021, 36 (1), 1-13. ISSN 1475-6366.
BAUTISTA-AGUILERA, Óscar M., L. ISMAILI, M. CHIOUA, R. ANDRÝS, M. SCHMIDT, P. BZONEK, M. ÁNGELES MARTÍNEZ-GRAU, CHD. BEADLE, T. VETMAN, F. LÓPEZ-MUÑOZ, I. IRIEPA, B. REFOUVELET, K. MUSÍLEK, J. MARCO-CONTELLES. Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer’s Disease Therapy. International journal of molecular sciences. 2020, 21 (11), "Article Number: 3913". ISSN 1661-6596.
SCHMIDT, Monika, O. BENEK, L. VINKLÁŘOVÁ, M. HRABINOVA, L. ZEMANOVÁ, M. CHRIBEK, V. KRALOVA, L. HROCH, R. DOLEŽAL, A. LYČKA, L. PRCHAL, D. JUN, L. AITKEN, F. GUNN-MOORE, K. KUČA, K. MUSÍLEK. Benzothiazolyl Ureas are Low Micromolar and Uncompetitive Inhibitors of 17 beta-HSD10 with Implications to Alzheimer's Disease Treatment. International journal of molecular sciences. 2020, 21 (6), "Article Number: 2059". ISSN 1661-6596.
GORECKI, Lukas, R. ANDRÝS, M. SCHMIDT, T. KUCERA, M. PSOTKA, B. SVOBODOVA, V. HRABCOVÁ, V. HEPNAROVA, P. BZONEK, D. JUN, K. KUČA, J. KORABECNY, K. MUSÍLEK. Cysteine-Targeted Insecticides against A. gambiae Acetylcholinesterase Are Neither Selective nor Reversible Inhibitors. ACS Medicinal Chemistry Letters. 2020, 11 (1), 65-71. ISSN 1948-5875.
VINKLÁŘOVÁ, Lucie, M. SCHMIDT, O. BENEK, K. KUČA, F. GUNN-MOORE, K. MUSÍLEK. Friend or enemy? Review of 17 beta-HSD10 and its role in human health or disease. JOURNAL OF NEUROCHEMISTRY. 2020, 155 (3), 231-249. ISSN 0022-3042.
ZEMANOVÁ, Lucie, M. VAŠKOVÁ, M. SCHMIDT, J. ROUBALOVÁ, A. HALEČKOVÁ, O. BENEK, K. MUSÍLEK. RNase T1 Refolding Assay for Determining Mitochondrial Cyclophilin D Activity: A Novel In Vitro Method Applicable in Drug Research and Discovery. Biochemistry. 2020, 59 (17), 1680-1687. ISSN 0006-2960.
AITKEN, Laura, O. BENEK, BE. MCKELVIE, RE. HUGHES, L. HROCH, M. SCHMIDT, LL. MAJOR, L. VINKLÁŘOVÁ, K. KUČA, TK. SMITH, K. MUSÍLEK, FJ. GUNN-MOORE. Novel Benzothiazole-Based Ureas as 17 beta-HSD10 Inhibitors, A Potential Alzheimer's Disease Treatment. Molecules. 2019, 24 (15), "Article Number: 2757". ISSN 1420-3049.
VANOVA, Nela, L. MUCKOVA, M. SCHMIDT, D. HERMAN, A. DLABKOVA, J. PEJCHAL, D. JUN. Simultaneous determination of malondialdehyde and 3-nitrotyrosine in cultured human hepatoma cells by liquid chromatography-mass spectrometry. Biomedical chromatography. 2018, 32 (12), 1-12. ISSN 0269-3879.
SCHMIDT, Monika, V. HRABCOVÁ, D. JUN, K. KUČA, K. MUSÍLEK. Vector Control and Insecticidal Resistance in the African Malaria Mosquito Anopheles gambiae. Chemical research in toxicology. 2018, 31 (7), 534-547. ISSN 0893-228X.
Životopis
Pozice a funkce na pracovišti
od 2016: Odborný asistent, Katedra chemie, Přírodovědecká fakulta, Univerzita Hradec Králové
Vzdělání, kvalifikace
2009 - 2014: Doktorské studium, Farmaceutický fakulta v Hradci Králové, Univerzita Karlova
2007 - 2009: Magisterské studium, Přírodovědecká fakulta, Masarykova Univerzita
2004 - 2007: Bakalářské studium, Přírodovědecká fakulta, Masarykova Univerzita
Přehled zaměstnání
od 2015: Výzkumný a vývojový pracovník, Centrum biomedicínského výzkumu, Fakultní nemocnice Hradec Králové
2013 - 2016: Akademický pracovník, Katedra epidemiologie, Fakulta vojenského zdravotnictví, Univerzita Obrany v Brně
