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prof. PharmDr. Kamil Musílek, Ph.D.
- Workplace: PřF - Faculty of Science
- vice-dean for International Affairs of the Faculty of Science
- Workplace: PřF - Department of Chemistry
- professor
- head of the Department of Chemistry
- E-mail: kamil.musilek@uhk.cz
- Phone: 493332780
- Building: S
- Room: 73840 3. floor
Academic profiles
UHK Publications
HANZLOVÁ, Michaela, B. SLAVIKOVÁ, M. MOROZOVOVÁ, K. MUSÍLEK, A. ROTTEROVÁ, L. ZEMANOVÁ, E. KUDOVÁ. C-3 Steroidal Hemiesters as Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 10. ACS Omega. 2024, 9 (10), 12116-12124. ISSN 2470-1343.
PRCHALOVÁ, Eliška, M. SUKUPOVA, D. MALIŇÁK, R. ANDRÝS, L. SIVAK, V. PEKARIK, A. SKARKA, J. SVOBODOVÁ, L. PRCHAL, L. FRESSER, Z. HEGER, K. MUSÍLEK. BODIPY-labelled acetylcholinesterase reactivators can be encapsulated into ferritin nanovehicles for enhanced bioavailability in the CNS. Biomedicine and Pharmacotherapy. 2023, 167 (November), "Article Number:115490". ISSN 0753-3322.
ROUSAR, Tomas, J. HANDL, J. CAPEK, P. NYVLTOVA, E. ROUSAROVA, M. KUBAT, L. SMID, J. VANOVA, D. MALIŇÁK, K. MUSÍLEK, P. CESLA. Cysteine conjugates of acetaminophen and p-aminophenol are potent inducers of cellular impairment in human proximal tubular kidney HK-2 cells. Archives of toxicology. 2023, 97 (11), 2943-2954. ISSN 0340-5761.
BENEK, Ondřej, M. VAŠKOVÁ, M. SEDLÁČEK MIŠKEŘÍKOVÁ, M. SCHMIDT, R. ANDRÝS, A. ROTTEROVÁ, A. SKARKA, J. HATLAPATKOVA, JZ. KARASOVA, M. MEDVECKÝ, L. HROCH, L. VINKLÁŘOVÁ, Z. FISAR, J. HROUDOVA, J. HANDL, J. CAPEK, T. ROUSAR, T. KOBRLOVA, R. DOLEZAL, O. SOUKUP, L. AITKEN, F. GUNN-MOORE, K. MUSÍLEK. Development of submicromolar 17 beta-HSD10 inhibitors and their in vitro and in vivo evaluation. European Journal of Medicinal Chemistry. 2023, 258 (říjen), "Article Number: 115593". ISSN 0223-5234.
HANZLOVÁ, Michaela, M. SEDLÁČEK MIŠKEŘÍKOVÁ, A. ROTTEROVÁ, K. CHALUPOVÁ, K. JURKOVÁ, M. HAMŠÍKOVÁ, R. ANDRÝS, A. HALEČKOVÁ, J. SVOBODOVÁ, M. SCHMIDT, O. BENEK, K. MUSÍLEK. Nanomolar Benzothiazole-Based Inhibitors of 17β-HSD10 with Cellular Bioactivity. ACS Medicinal Chemistry Letters. 2023, 14 (12), 1724-1732. ISSN 1948-5875.
SCHMIDT, Monika, M. VAŠKOVÁ, A. ROTTEROVÁ, P. FIANDOVÁ, M. MIŠKEŘÍKOVÁ, L. ZEMANOVÁ, O. BENEK, K. MUSÍLEK. Physiologically relevant fluorescent assay for identification of 17β-hydroxysteroid dehydrogenase type 10 inhibitors. Journal of Neurochemistry. 2023, 167 (2), 154-167. ISSN 0022-3042.
JŮZA, Radomír, K. MUSÍLEK, E. MEZEIOVA, O. SOUKUP, J. KORABECNY. Recent advances in dopamine D-2 receptor ligands in the treatment of neuropsychiatric disorders. Medicinal Research Reviews. 2023, 43 (1), 55-211. ISSN 0198-6325.
MIKYSKOVA, Romana, O. SAPEGA, M. PSOTKA, O. NOVOTNY, Z. HODNY, S. BALINTOVA, D. MALIŇÁK, J. SVOBODOVÁ, R. ANDRÝS, D. RYSANEK, K. MUSÍLEK, M. REINIS. STAT3 inhibitor Stattic and its analogues inhibit STAT3 phosphorylation and modulate cytokine secretion in senescent tumour cells. Molecular Medicine Reports. 2023, 27 (4), "Article Number: 81". ISSN 1791-2997.
PRCHALOVÁ, Eliška, Z. KOHOUTOVÁ, K. KNITTELOVÁ, D. MALIŇÁK, K. MUSÍLEK. Strategies for enhanced bioavailability of oxime reactivators in the central nervous system. Archives of toxicology. 2023, 97 (11), 2839-2860. ISSN 0340-5761.
OLEKŠÁK, Patrik, E. NEPOVIMOVÁ, Ž. CHRIENOVÁ, K. MUSÍLEK, J. PATOČKA, K. KUČA. Contemporary mTOR inhibitor scaffolds to diseases breakdown: A patent review (2015–2021). European Journal of Medicinal Chemistry. 2022, 238 (August), "Article number: 114498". ISSN 0223-5234.
ZORBAZ, Tamara, D. MALIŇÁK, T. HOFMANOVÁ, N. MARAKOVIC, S. ZUNEC, NM. HRVAT, R. ANDRÝS, M. PSOTKA, A. ZANDONA, J. SVOBODOVÁ, L. PRCHAL, S. FINGLER, M. KATALINIC, Z. KOVARIK, K. MUSÍLEK. Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents. European Journal of Medicinal Chemistry. 2022, 238 (August), "Article Number: 114377". ISSN 0223-5234.
ZHAO, Yingying, K. KUČA, W. WU, X. WANG, E. NEPOVIMOVÁ, K. MUSÍLEK, Q. WU. Hypothesis: JNK signaling is a therapeutic target of neurodegenerative diseases. ALZHEIMERS & DEMENTIA. 2022, 18 (1), 152-158. ISSN 1552-5260.
KOHOUTOVÁ, Zuzana, D. MALIŇÁK, R. ANDRÝS, J. SVOBODOVÁ, M. PSOTKA, M. SCHMIDT, L. PRCHAL, K. MUSÍLEK. Charged pyridinium oximes with thiocarboxamide moiety are equally or less effective reactivators of organophosphate-inhibited cholinesterases compared to analogous carboxamides. Journal of enzyme inhibition and medicinal chemistry. 2022, 37 (1), 760-767. ISSN 1475-6366.
UNIVERZITA HRADEC KRÁLOVÉ. Monopyridiniové soli pro reaktivaci organofosfáty inhibované acetylcholinesterasy, Původci: MUSÍLEK, Kamil, D. MALIŇÁK, O. BENEK2022. Číslo patentu: 309 329.
JŮZA, Radomír, I. VOJTECHOVA, K. STEFKOVA-MAZOCHOVA, W. DEHAEN, T. PETRASEK, L. PRCHAL, T. KOBRLOVA, J. JANOUSEK, P. VLCEK, E. MEZEIOVA, D. SVOZIL, JZ. KARASOVA, J. PEJCHAL, H. STARK, GJ. SATALA, AJ. BOJARSKI, M. KUBACKA, S. MOGILSKI, A. RANDAKOVA, K. MUSÍLEK, O. SOUKUP, J. KORABECNY. Novel D-2/5-HT receptor modulators related to cariprazine with potential implication to schizophrenia treatment. European Journal of Medicinal Chemistry. 2022, 232 (15.3.2022), "Article Number 114193". ISSN 0223-5234.
VANOVA, Jana, D. MALIŇÁK, R. ANDRÝS, M. KUBAT, T. MIKYSEK, E. ROUSAROVA, K. MUSÍLEK, T. ROUSAR, P. CESLA. Optimization of gradient reversed phase high performance liquid chromatography analysis of acetaminophen oxidation metabolites using linear and non-linear retention model. Journal of Chromatography A. 2022, 1669 (April), "Article Number: 462956". ISSN 0021-9673.
ZHANG, L., K. KUČA, L. YOU, Y. ZHAO, K. MUSÍLEK, E. NEPOVIMOVÁ, Q. WU, W. WU, V. ADAM. Signal transducer and activator of transcription 3 signaling in tumor immune evasion. Pharmacology and Therapeutics. 2022, 230 (February), "Article number: 107969". ISSN 0163-7258.
HALEČKOVÁ, Annamária, O. BENEK, L. ZEMANOVÁ, R. DOLEŽAL, K. MUSÍLEK. Small-molecule inhibitors of cyclophilin D as potential therapeutics in mitochondria-related diseases. Medicinal Research Reviews. 2022, 42 (5), 1822-1855. ISSN 0198-6325.
KARASOVA, Jana Zdarova, J. KASSA, V. HEPNAROVA, J. PEJCHAL, L. JUNOVA, R. ANDRÝS, D. MALIŇÁK, P. BZONEK, Z. KOHOUTOVÁ, K. MUSÍLEK. Toxicity, pharmacokinetics, and effectiveness of the ortho-chlorinated bispyridinium oxime, K870. Food and chemical toxicology. 2022, 167 (September), "Article Number: 113236". ISSN 0278-6915.
ISMAILI, Lhassane, J. MONNIN, A. ETIEVANT, RL. ARRIBAS, L. VIEJO, B. REFOUVELET, O. SOUKUP, J. JANOCKOVA, V. HEPNAROVA, J. KORABECNY, T. KUCERA, D. JUN, R. ANDRÝS, K. MUSÍLEK, A. BAGUET, EM. GARCIA-FRUTOS, A. DE SIMONE, V. ANDRISANO, M. BARTOLINI, C. DE LOS RIOS, J. MARCO-CONTELLES, E. HAFFEN. (+/-)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3 beta Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease. ACS Chemical Neuroscience. 2021, 12 (8), 1328-1342. ISSN 1948-7193.
Resume
Position
2019 - 2022: Vice-dean for International Affairs
2011 - 2022: Head of Department of Chemistry
Education and Qualifications
2019: Full Professor in Pharmaceutical Chemistry
2012: Associate Professor in Pharmaceutical Chemistry
2008: PharmDr. in Pharmaceutical Chemistry
2004 - 2007: Ph.D. in Pharmaceutical Chemistry
1999 - 2004: MSc. in Pharmacy
Work Experience
2011 - 2022: academic position, University of Hradec Kralove, Faculty of Science
2011 - 2022: scientific position, University Hospital Hradec Kralove
2006 - 2018: academic position, University of Defence, Faculty of Military Health Sciences
Teaching Experience
Medicinal Chemistry
Organic and Bioorganic Chemistry
Toxicology
Academic Stays Abroad
2009: Centre Recherche Service Santé Armée, La Tronche/Grenoble, FR
2007: University St Andrews, UK
2003 - 2004: Ruprecht-Karls-Universität Heidelberg, DE
